Myeloperoxidase cytochemistry using 2, 7-fluorenediamine.
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Myeloperoxidase cytochemistry using 2, 7-fluorenediamine.
The myeloperoxidase cytochemical reaction has been well established as a valuable tool in the characterisation of various types of leucocytes. This method helps in the distinction between acute myeloid leukaemias (AML) and acute lymphoblastic leukaemias (ALL) as suggested in the French, American, and British (FAB) classification (Bennett et al., 1976). The most common substrates used are benzid...
متن کاملThe measurement of neutrophil myeloperoxidase by flow cytochemistry is influenced by the pseudoperoxidase activity of hemoglobin.
Gulley et all have recently reported increased neutrophil myeloperoxidase (MPO) activity in 10 anemic patients demonstrated by the Technicon H* l instrument (Technicon Instruments Corp, Tarrytown, NY). Dash et ai2 have commented on this report for not considering the balance of smokers to nonsmokers. We would like to comment further on this report. It has been shown by us that the neutrophil MP...
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Numerous studies have suggested relationships between myeloperoxidase (MPO), inflammation, and atherosclerosis. MPO-derived reactive chlorinating species attack membrane plasmalogens releasing alpha-chloro fatty aldehydes including 2-chlorohexadecanal (2-ClHDA), which have been found to accumulate in activated neutrophils, activated monocytes, infarcted myocardium and human atheromas. The prese...
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ژورنال
عنوان ژورنال: Journal of Clinical Pathology
سال: 1978
ISSN: 0021-9746
DOI: 10.1136/jcp.31.11.1114